Antimicrobial Resistance (AMR) is resistance of a microorganism to an antimicrobial medicine to which it was originally sensitive. Resistant organisms are able to withstand attack by antimicrobial medicines, such as antibiotics, antifungals, antivirals, and antimalarials, so that standard treatments become ineffective and infections persist, increasing risk of spread to others. The evolution of resistant strains is a natural phenomenon that happens when microorganisms are exposed to antimicrobial drugs, and resistant traits can be exchanged between certain types of bacteria. The misuse of antimicrobial medicines accelerates this natural phenomenon and poor infection control practices encourage the spread of AMR. The development of AMR is a natural phenomenon. However, certain human actions actually accelerate the emergence and spread of AMR. AMR is a complex problem driven by many interconnected factors, so single and isolated interventions have little impact and coordinated actions are required. This Forum will focus on the actions that can be taken to combat AMR, including fostering coordinated actions by all stakeholders, creating policy guidance, supporting surveillance, providing technical assistance, and fostering innovation in research and development.